127202-28-2Relevant academic research and scientific papers
Crossed aldol reaction using cross-linked polymer-bound lithium dialkylamide
Seki, Atsushi,Ishiwata, Fusae,Takizawa, Youichi,Asami, Masatoshi
, p. 5001 - 5011 (2007/10/03)
Cross-linked polymer-bound lithium dialkylamides were employed in crossed aldol reaction of various carbonyl compounds with aldehydes to afford the corresponding β-hydroxycarbonyl compounds. The introduction of spacer chains to the polymer-bound lithium d
Cobalt(II) Catalyzed Coupling Reaction of α,β-Unsaturated Compounds with Aldehydes by the Use of Phenylsilane. New Method for Preparation of β-Hydroxy Nitriles, Amides, and Esters
Isayama, Shigeru,Mukaiyama, Teruaki
, p. 2005 - 2008 (2007/10/02)
A new crossed coupling reaction of α,β-unsaturated nitriles with aldehydes was performed by using phenylsilane and a catalytic amount of bis(1,3-diketonato)cobalt(II) to give β-siloxy nitriles in good yields.Similarly, α,β-unsaturated amides and esters also reacted under the same conditions to afford β-siloxy amides or esters.The present reaction provides a new and facile method for preparation of β-hydroxy nitriles, amides, and esters.
