127218-61-5

Upstream product

• 127205-14-5 2,2-dimethyl-5-hydroxy-5-(2'-hydroxyethyl)-1,3-dioxane 
• 98-59-9 p-toluenesulfonyl chloride 
• 53104-32-8 (5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol 
• 74181-34-3 2,2,-dimethyl-1,3-dioxan-5-one 
• 633308-04-0 2,2-dimethyl-5-(prop-2-enyl)-1,3-dioxan-5-ol 
• 633308-05-1 3-(2,2-dimethyl-5-hydroxy-1,3-dioxan-5-yl)propane-1,2-diol 
• 127205-12-3 2,2-dimethyl-5-(2'-hydroxyethyl)-5-methoxy-1,3-dioxane 
• 127205-10-1 5-allyl-2,2-dimethyl-5-methoxy-1,3-dioxane 

Downstream Products

• 127205-20-3 2-amino-6-benzyloxy-9-<2'-(2,2-dimethyl-5-hydroxy-1,3-dioxan-5-yl)ethyl>-9H-purine 
• 633308-18-6 2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate) 
• 633308-15-3 2-[(dodecanoyloxy)methyl]-2-hydroxy-4-[(4-nitrophenyl)oxy]butyl dodecanoate 
• 633308-13-1 2-[(decanoyloxy)methyl]-2-hydroxy-4-[(4-nitrophenyl)oxy]butyl decanoate 
• 633308-17-5 2-hydroxy-2-(hydroxymethyl)-4-[(4-nitrophenyl)oxy]butyl decanoate 
• 633308-11-9 2-(acetoxymethyl)-2-hydroxy-4-[(4-nitrophenyl)oxy]butyl acetate 
• 633308-09-5 2-(hydroxymethyl)-4-[(4-nitrophenyl)oxy]butane-1,2-diol 

Relevant academic research and scientific papers

Synthesis and evaluation of chromogenic and fluorogenic analogs of glycerol for enzyme assays

The branched glycerol analogs 1 and 2 were prepared. Mono-ester derivatives of these triols undergo a chromogenic or fluorogenic reaction in the presence of NaIO4. In contrast, both the diesters and the triols are themselves not chromogenic or fluorogenic. Diester derivatives of these triols can be used as probes for lipases. The tris-phosphate derivative of 1 is a fluorogenic substrate for various phosphatases.

Antiviral acyclonucleosides and acyclonucleotides

Disclosed are compounds of the formula: wherein B is related to one of the heterocyclic bases found in nucleic acid (DNA, RNA) such as a purine, a substituted purine, a pyrimidine or a substituted pyrimidine wherein the substituents on the purine or pyrimidine are selected from amino, hydroxyl, halogen, thio or alkylthiol wherein the alkyl moiety of the alkylthiol has 1 to 6 carbons; R1 is fluorine, chlorine, hydroxy, alkoxy having 1 to 6 carbons or a phosphate group having the formula: wherein R4 and R5 are pharmaceutically acceptable cations; R2 and R3 are independently hydroxy, alkoxy having 1 to 6 carbons or a phosphate group having the formula: wherein R4 and R5 hydrogen or are pharmaceutically acceptable cations; or two of R1, R2 and R3 taken together form a phosphate group having the formula: wherein R4 is hydrogen or a pharmaceutically acceptable cation. The compounds have antiviral activity. They are particularly effective against the herpes group of viruses with special utility against cytomegalovirus (CMV) and varicella-zoster virus (VZV), and against retroviruses such as HTLV-III.

Carba-acyclonucleoside antiherpetic agents

Ganciclovir 2 and 2'-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy an