127223-95-4

Basic information

• Product Name: 1,1,1-TRIFLUORO-4-ISOPROPYLAMINOPENT-3-EN-2-ONE
• Synonyms: 1,1,1-TRIFLUORO-4-ISOPROPYLAMINOPENT-3-EN-2-ONE;1,1,1-TRIFLUORO-4-(ISOPROPYLAMINO)PENT-3-(Z)-ENE-2-ONE
• CAS NO: 127223-95-4
• Molecular Formula: C8H12F3NO
• Molecular Weight: 195.18
• Mol File: 127223-95-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 165.9°C at 760 mmHg
• Flash Point: 54.1°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 1.84mmHg at 25°C
• Refractive Index: 1.402
• CAS DataBase Reference: 1,1,1-TRIFLUORO-4-ISOPROPYLAMINOPENT-3-EN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUORO-4-ISOPROPYLAMINOPENT-3-EN-2-ONE(127223-95-4)
• EPA Substance Registry System: 1,1,1-TRIFLUORO-4-ISOPROPYLAMINOPENT-3-EN-2-ONE(127223-95-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 127223-95-4(Hazardous Substances Data)

Usage

Description

1,1,1-Trifluoro-4-isopropylaminopent-3-en-2-one, commonly known as Trifluoperazine, is a synthetic chemical compound with the molecular formula C11H16F3NO. It is primarily recognized as an antipsychotic medication and tranquilizer, which functions by inhibiting the activity of specific brain chemicals, such as dopamine and serotonin. This action is instrumental in mitigating the symptoms of schizophrenia and other psychotic disorders, as well as managing severe behavioral issues and symptoms of anxiety and agitation in both children and adults.

Uses

Used in Pharmaceutical Industry:
1,1,1-Trifluoro-4-isopropylaminopent-3-en-2-one is used as an antipsychotic medication for the treatment of schizophrenia and other psychotic disorders. It is effective in alleviating symptoms by blocking the action of dopamine and serotonin in the brain.
1,1,1-Trifluoro-4-isopropylaminopent-3-en-2-one is also used as a tranquilizer to treat severe behavioral problems in children and adults, as well as to manage symptoms of anxiety and agitation. Its calming effects are beneficial in these situations.

InChI:InChI=1/C8H12F3NO/c1-5(2)12-6(3)4-7(13)8(9,10)11/h4-5,12H,1-3H3/b6-4-

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 75-31-0 isopropylamine 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 108-18-9 diisopropylamine 
• 135351-20-1 1,1,1-trifluoro-4-methoxypent-3-en-2-one 

Relevant articles and documents

Redox Property of Enamines

Enamines are electron-rich compounds bearing intriguing redox properties. Herein, a series of secondary enamines condensed from primary amine and β-ketocarbonyls were synthesized and their electrochemical oxidation properties were systematically studied by cyclic voltammetry. Furthermore, theoretical calculation of oxidation potentials of enamines, particularly those catalytic intermediates, was also conducted to further broaden the scope investigated. Possible structural factors on oxidation and the nature of the resulted radical cation intermediates were revealed and discussed. Correlation of redox potentials with molecular properties such as highest occupied molecular orbital energies and natural population analysis charge were explored, and there appears no simple linear correlation. On the other hand, a good correlation with Mayr's nucleophilicity parameter N was noted among a range of catalytically relevant enamines. Spin population analysis disclosed that enamine radical cations mainly exhibit the carbon-center free radical feature. Taking experimental and computation data together, a comprehensive picture about the redox property of enamines is presented, which would provide guidance in the development of oxidative enamine catalysis and transformations.

O-N, S-N AND N-N EXCHANGE REACTIONS AT OLEFINIC CARBON ATOMS: FACILE SYNTHETIC METHOD FOR β-TRIFLUOROACETYLVINYLAMINES

β-Trifluoroacetylvinyl ethers 1 and sulfides 2 react easily with various amines at room temperature to give β-trifluoroacetylvinylamines 3 in excellent yields.This O-N and S-N exchange reaction can be extended to N-N exchange reaction.