127229-76-9

Upstream product

• 127229-64-5 Ethyl 2-chloro-2,3-dimethyl-3-butenoate 
• 100-46-9 benzylamine 
• 13979-28-7 ethyl 2,3-dimethylbut-2-enoate 
• 144173-20-6 1-Benzyl-3,4-dimethyl-2,5-dihydrofuran-2-one 
• 4383-22-6 Allylbenzylamine 
• 42856-52-0 1-benzyl-3,4-dimethyl-2,5-pyrrolidinedione 

Relevant academic research and scientific papers

Synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one by Novel Palladium(II)-Catalyzed Cyclization and Ring-Closing Metathesis

Synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one is described starting from commercially available allylamine and 4-methoxybenzylamine employing palladium-catalyzed cyclization or ring-closing metathesis as the key steps.

Synthesis of γ-Butyrolactams by the Palladium-Catalyzed Cyclization of N-Allylbromoacetamides

N-Allylbromoacetamides undergo cyclizatlon to give γ-butyrolactams in the presence of palladium catalysts and a base. - Key words: Palladium-catalyzed cyclization; γ-Butyrolactam.

Reduction of five-membered α,β-unsaturated lactones and related compounds with the Ni2+/BH4- system

The reductions of an α,β-unsaturated lactone (5) and lactam (7) with the Ni2+/BH4- system resulted in the formation of cis-hydrogenated products (8a and 9a) with high stereoselectivity. The cis products (8a and 9a) were ea

Synthesis and Reactions of α-Chloro-β,γ-unsaturated Esters. 1

Four new α-chloro-β,γ-unsaturated esters were prepared in good yield by the reaction of hypochlorous acid with substituted ethyl 2-butenoates.Reaction of these substituted allylic chlorides with several nucleophiles has been investigated.Thiophenol in the presence of aqueous sodium hydroxide react with ethyl 2-chloro-3-methyl-3-butenoate (2) to give 6, whereas ethyl 2-chloro-2,3-dimethyl-3-butenoate (1) is unreactive.Tertiary allylic chlorides 1, 3 and 4 react with secondary amines to give exclusive abnormal SN2 reaction products.With benzylamine abnormal SN2 substitution is followed by cyclization to give 1-benzyl-3-pyrrolin-2-ones.While ethyl lithioacetate reacts with 1 to give acylation product 18, sodium diphenylmethide in liquid ammonia undergoes alkylation on the tertiary carbon possibly by an electron-transfer reaction pathway.Lithio-1,3-dithiane reacts with 1 to give 2,3-dimethyl-6,10-dithiaspirodec-2-en-1-one (20) via a two-step process, viz., acylation followed by anovel variation of the intramolecular abnormal SN2 reaction.Raney nickel desulfurization of 20 gave 2,3-dimethyl-2-cyclopenten-1-one.Synthetic and mechanistic implications of these results are discussed.