127237-71-2

Upstream product

• 127237-72-3 (1-Pyrrolidin-1-ylmethyl-1H-[1,2,4]triazol-3-yl)-p-tolyl-methanol 
• 91272-81-0 1-pyrrolidin-1-ylmethyl-1H-[1,2,4]-triazole 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 127237-72-3 (1-Pyrrolidin-1-ylmethyl-1H-[1,2,4]triazol-3-yl)-p-tolyl-methanol 

Relevant academic research and scientific papers

Synthesis of 3(5)-substituted 1,2,4-triazoles by lithiation of 1-(1-pyrrolidinomethyl)-1,2,4-triazole

1,2,4-Triazole 1 is readily converted into 3(5)-substituted 1,2,4-triazoles 4 by a three-step sequence: (i) Mannich reaction with formaldehyde and pyrrolidine; (ii) lithiation of 1-(1-pyrrolidinomethyl)-1, 2,4-triazole 2, followed by addition of an electrophile; (iii) deprotection of the N-aminal groups of the N-protected 3-substituted 1,2,4-triazoles 3 using sodium borohydride (NaBH4) in ethanol. 3(5)-Substituted 1,2,4-triazoles 4 result in good overall yields.