127237-74-5Relevant academic research and scientific papers
Asymmetric induction using chiral 1,2,4-triazole arad benzimidazole derivatives
Katritzky, Alan R.,Aslan, Diana C.,Leeming, Peter,Steel, Peter J.
, p. 1491 - 1500 (2007/10/03)
Lithiated N-substituted 1,2,4-triazoles 3 and 8 and benzimidazole 11 reacted with (1R)-fenchone to give derivatives 5c, 9 and 12 in good yields as single diastereoisomers, (S)-Lactic acid 16 reacted with o-phenylenediamine 15 to give optically pure (S)-2-
Synthesis of 3(5)-substituted 1,2,4-triazoles by lithiation of 1-(1-pyrrolidinomethyl)-1,2,4-triazole
Katritzky, Alan R.,Lue, Ping,Yannakopoulou, Konstantina
, p. 641 - 648 (2007/10/02)
1,2,4-Triazole 1 is readily converted into 3(5)-substituted 1,2,4-triazoles 4 by a three-step sequence: (i) Mannich reaction with formaldehyde and pyrrolidine; (ii) lithiation of 1-(1-pyrrolidinomethyl)-1, 2,4-triazole 2, followed by addition of an electrophile; (iii) deprotection of the N-aminal groups of the N-protected 3-substituted 1,2,4-triazoles 3 using sodium borohydride (NaBH4) in ethanol. 3(5)-Substituted 1,2,4-triazoles 4 result in good overall yields.
