127258-19-9

Upstream product

• 128694-56-4 ((1R,5R)-5-Methoxy-cyclohex-3-enylmethylsulfanyl)-benzene 
• 127258-16-6 (1R,5R)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-2-cyclohexene 
• 127258-15-5 (1R,5R)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2-cyclohexen-1-ol 
• 127258-17-7 (1R,5R)-5-(hydroxymethyl)-1-methoxy-2-cyclohexene 
• 109667-78-9 N-(4-chloro-7-oxo-6-oxabicyclo[3.2.1]octan-3-yl)acetamide 
• 127308-75-2 (1R,5R)-5-(hydroxymethyl)-2-cyclohexen-1-ol 
• 5709-98-8 (R)-cyclohex-3-enecarboxylic acid 
• 873-55-2 sodium benzenesulfonate 
• 127258-18-8 (1R,5R)-5-(iodomethyl)-1-methoxy-2-cyclohexene 
• 128892-41-1 5-Phenylsulphonylmethylcyclohex-2-en-1-one 
• 128892-42-2 5-Phenylsulphonylmethylcyclohex-2-en-1-ol 
• 74-88-4 methyl iodide 

Downstream Products

• 127258-20-2 2-Methoxy-4-phenylsulphonylmethylcyclohexan-1-ol 
• 128694-54-2 ((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane 
• 128716-86-9 tert-Butyl-{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-diphenyl-silane 
• 128694-53-1 (3S,4S)-1-[(1R,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one 
• 128694-61-1 (3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one 
• 128694-60-0 (3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-ol 
• 128716-87-0 Trifluoro-methanesulfonic acid (2S,3S)-1-[1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-meth-(Z)-ylidene]-3-[1,3]dithian-2-yl-2-(4-methoxy-benzyloxy)-butyl ester 
• 118207-43-5 (1R,2R,4R)-2-methoxy-4-<(phenylsulfonyl)methyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>cyclohexane 
• 127258-23-5 (1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane 
• 127258-22-4 ((1R,3S,5R)-3-Benzenesulfonylmethyl-5-methoxy-cyclohexyloxy)-tert-butyl-dimethyl-silane 
• 127258-20-2 (1R,2R,4R)-2-methoxy-4-<(phenylsulfonyl)methyl>-1-cyclohexanol 
• 127258-21-3 (1R,3R,5R)-3-Benzenesulfonylmethyl-5-methoxy-cyclohexanol 
• 128892-43-3 2-Methoxy-4-phenylsulphonylmethylcyclohexyl acetate 
• 118207-43-5 1-(t-Butyldimethylsilyloxy)-2-methoxy-4-phenylsulphonylmethylcyclohexane 

Relevant academic research and scientific papers

Efficient Preparation of Intermediates Corresponding to C22-C27 and C28-C34 of FK-506

Efficient large-scale preparations of aldehyde 2 and sulfone 3 representing the C22-C27 and C28-C34 potions of the immunosuppressant FK-506 (1) are descibed.

An Approach to the Cyclohexyl Moiety of the Immunosuppressive Agent FK-506

Tricarbonyl(3-methoxycyclohexadienyl)iron hexafluorophosphate, which is readily prepared from 1,3-dimethoxybenzene, was treated with the enolate of methyl phenylsulphonylacetate to give an adduct which was decarboxylated and decomplexed to give 5-phenylsu

FK-506 SYNHETIC STUDIES. 3. AN EFFICIENT ASYMMETRIC SYNTHESIS OF THE C(24)-C(34) FRAGMENT OF FK-506, FR-900520, AND FR-900523

An efficient asymmetric synthesis of the C(24)-C(34) fragment of the FK-506 family of immunosuppressants has been achieved.