1272599-08-2Relevant academic research and scientific papers
Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo
Shimizu, Hiroki,Yasumatsu, Isao,Hamada, Tomoaki,Yoneda, Yoshiyuki,Yamasaki, Tomonori,Tanaka, Shinji,Toki, Tadashi,Yokoyama, Mika,Morishita, Kaoru,Iimura, Shin
scheme or table, p. 904 - 908 (2011/03/21)
We have increased the potency of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors with two strategies. One is to enhance the activity in cell-based assay by adjusting the polarity of molecules to improve permeability. Another is to increase the affinity for IKKβ by the introduction of additional substituents based on the hypothesis derived from an interaction model study. These improved compounds showed inhibitory activity of TNFα production in mice.
