127264-12-4Relevant academic research and scientific papers
Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2a ligands for PET or SPECT brain imaging
Fu, Xing,Tan, Ping-Zhong,Kula, Nora S.,Baldessarini, Ross,Tamagnan, Gilles,Innis, Robert B.,Baldwin, Ronald M.
, p. 2319 - 2324 (2007/10/03)
A series of 4′-substituted phenyl-4-piperidinylmethanol and benzoyl-4-piperidine derivatives was synthesized as potential novel serotonin 5-HT2A receptor ligands that can be radiolabeled for in vivo brain imaging. Compounds were prepared by alk
1-ARYLETHYL-3-SUBSTITUTED PIPERIDINES
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, (2008/06/13)
A series of novel 1-(phenethyl) and 1-(1-heteroarylethyl)-3-substituted piperidine derivatives have been prepared, including their pharmaceutically acceptable salts and various novel key intermediates therefor. The 3-substituent present in these compounds is an unsubstituted or substituted diphenylmethoxy group or a diphenylmethoxy-derived group, while the 1-substituent is unsubstituted or substituted phenethyl or 1-(2-heteroarylethyl) wherein the heteroaryl moiety is thienyl, pyridyl or pyrazinyl. These compounds in the form of both their racemates and 3R-isomers, are useful in therapy as smooth muscle muscarinic receptor antagonists and therefore, are of value in the treatment diseases associated with altered motility and/or smooth muscle tone. The most preferred compound is (3R)-diphenylmethoxy-1-(3,4-methylenedioxyphenethyl)piperidine. Methods for preparing these compounds from known starting materials are provided.
