1272675-97-4Relevant academic research and scientific papers
An efficient synthesis of 3-substituted 3H-isobenzofuran-1-ylidenamines by the reaction of 2-cyanobenzaldehydes with organolithiums and their conversion into isobenzofuran-1(3h)-ones
Kobayashi, Kazuhiro,Matsumoto, Kota,Konishi, Hisatoshi
experimental part, p. 99 - 106 (2011/04/22)
A new and efficient synthesis of 3-substituted 3H-isobenzofuran-1- ylidenamines by the reaction of 2-cyanobenzaldehydes with nucleophiles, such as organolithiums or lithium enolates of t-butyl acetate and N,Ndimethylacetamide, is reported. Some of these products were converted into the corresponding 3-substituted isobenzofuran-1(3H)-ones (phthalides) upon treatment with hydrochloric acid in satisfactory yields. The Japan Institute of Heterocyclic Chemistry.
