127273-06-7Relevant academic research and scientific papers
GLP RECEPTOR AGONISTS
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Page/Page column 30; 33, (2021/09/26)
The disclosures herein relate to novel compounds of formula (1 ): and salts thereof, wherein Q, W, X, Y, Z, AA1, AA2, AA3, AA4, AA5, AA6, AA7, AA8, AA9, LysR, R1, R2 and n are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with Glucagon-like peptide (GLP) receptors.
ORAL GLP RECEPTOR AGONISTS
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Page/Page column 44; 47, (2021/09/26)
The disclosures herein relate to novel compounds of formula (1a) or formula (1b): and salts thereof, wherein S, T, W, Z, AA1, AA2, AA3, AA4, AA5, AA6, AA7, AA8, AA9, AA10, AA11, AA12, AA13, AA14, AA15, A16, AA17, AA18, AA19, AA20, AA21, AA22, Sa, Ta, Wa, Xa, Ya, Za, AA1a, AA2a, AA3a, AA4a, AA 5a, AA 6a,AA 7a,AA8a,AA 9a,AA 10a,AA11a,AA 12a,AA13aAA 14a,AA15a,AA 16a, R, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with Glucagon-like peptide (GLP) receptors.
Tetrazole analogues of aspartic, glutamic and α-aminoadipic acids and their derivatives with tetrazole ring in side chains useful for solid-phase peptide synthesis
Manturewicz,Grzonka
, p. 2121 - 2131 (2008/09/18)
Tetrazole analogues of Fmoc-aspartic, -glutamic and -α-aminoadipic acids with acidic tetrazolyl group in side chains suitable for solid-phase peptide synthesis were obtained. Moreover, the appropriate derivatives of aspartic and glutamic acids containing tetrazole ring methylated in position N1 or N2 were synthesized as well.
Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides
Sureshbabu, Vommina V.,Venkataramanarao, Rao,Naik, Shankar A.,Chennakrishnareddy
, p. 7038 - 7041 (2008/03/12)
An efficient synthesis of tetrazole analogues of amino acids starting from Nα-Fmoc amino acid in a three-step protocol is reported. The free amino tetrazoles were obtained in good yields and with excellent purity after removal of the Fmoc group
