1272758-17-4

Basic information

• Product Name: 2-Boc-8-oxo-2-azaspiro[4.5]decane
• Synonyms: 2-Boc-8-oxo-2-azaspiro[4.5]decane;tert-butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate;2-Boc-8-oxo-2-azaspiro[4.5]decane - X11425
• CAS NO: 1272758-17-4
• Molecular Formula: C14H23NO3
• Molecular Weight: 253.33732
• Mol File: 1272758-17-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Boc-8-oxo-2-azaspiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Boc-8-oxo-2-azaspiro[4.5]decane(1272758-17-4)
• EPA Substance Registry System: 2-Boc-8-oxo-2-azaspiro[4.5]decane(1272758-17-4)

Safety Data

• Hazardous Substances Data: 1272758-17-4(Hazardous Substances Data)

Usage

General Description

2-Boc-8-oxo-2-azaspiro[4.5]decane, also known as Boc-protected azabicyclic ketone, is a chemical compound with a bicyclic structure containing a spiro-ring system. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and biologically active compounds. The Boc (tert-butoxycarbonyl) group is a protecting group commonly used in organic chemistry to protect and activate specific functional groups during chemical reactions. The presence of the Boc group in 2-Boc-8-oxo-2-azaspiro[4.5]decane makes it a versatile intermediate in the synthesis of various pharmacologically relevant compounds. Its unique structure and functionality make it a valuable tool for drug discovery and development in the pharmaceutical industry.

Upstream product

• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 
• 1292278-70-6 9,12-dioxa-3-azadispiro[4.2.4⁸.2⁵]tetradecan-4-one 
• 914780-95-3 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one 
• 1246508-12-2 ethyl 2-(8-(nitromethyl)-1,4-dioxaspiro-[4,5]-decan-8-yl-acetate) 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 51656-91-8 ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Preparation method of tert-butyl-8-oxo-2-azaspiro-[4.5] decane-2-formate

The invention relates to a preparation method of tert-butyl-8-oxo-2-azaspiro-[4.5] decane-2-formate, and mainly aims to solve the technical problems of high raw material cost, difficulty in reaction control, inconvenience in experimental operation and the like in an existing synthesis process. According to the method, tert-butyl-8-oxo-2-azaspiro-[4.5] decane-2-formate is prepared from cheap and easily available 1, 4-dioxaspiro [4.5] decane-8-one as an initial raw material through four steps of reaction. The reaction formula is shown in the specification. The tert-butyl-8-oxo-2-azaspiro-[4.5] decane-2-formate obtained in the invention is a useful intermediate or product synthesized from a plurality of medicines.

Substituted heteroaryl compounds and compositions and uses thereof

The invention provides a substituted heteroaryl compound and a composition thereof, and applications of the compound and the composition. The compound is a compound as shown in a formula I, or stereoisomer, tautomer, oxynitride, solvate, metabolite, pharmaceutically-acceptable salt or prodrug of the compound as shown in the formula I. The invention also provides a pharmaceutical composition containing the above-mentioned compound; and the above-mentioned compound and the pharmaceutical composition are capable of adjusting the activity of JAK kinases and are applied in prevention, treatment, therapy and alleviation of JAK kinase mediated diseases or disorders.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a JAK-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated disease.