127280-36-8Relevant academic research and scientific papers
Diols obtained via chemo and regioselective ring opening of epoxy alcohols: A straightforward synthesis of 2S,3S-octandiol
Bonini, Carlo,Righi, Giuliana
, p. 1531 - 1538 (2007/10/02)
Epoxy alcohols are regio and chemoselectively opened to the corresponding iodohydrins and then reduced in situ to diols; the application of the described procedure leads to a short asymmetric of a well known pheromone. Also homoallylic (E and Z) epoxy alcohols and its benzylated derivatives shows high preference for regioselective opening affording the corresponding 1,3 diol.
Mild and Stereocontrolled Synthesis of Iodo- and Bromohydrins by X2-Ti(O-i-Pr)4 Opening of Epoxy Alcohols
Alvarez, Eleuterio,Nunez, Maria Teresa,Martin, Victor S.
, p. 3429 - 3431 (2007/10/02)
A mild procedure to obtain halo diols by opening epoxy alcohols with halogen is described.The method is based on the use of Ti(O-i-Pr)4 and the suitable halogen over allylic and homoallylic epoxy alcohols, affording high regioselectivities and yields.Reaction with enantiomerically enriched epoxides leads selectively to chiral halohydrins.
