1273-42-3Relevant academic research and scientific papers
Synthesis of ferrocene derivatives with planar chirality via palladium-catalyzed enantioselective C-H bond activation
Pi, Chao,Cui, Xiuling,Liu, Xiuyan,Guo, Mengxing,Zhang, Hanyu,Wu, Yangjie
supporting information, p. 5164 - 5167 (2014/12/11)
The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series of 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient and concise one-pot conditions with up to 85% yield and 98% ee. The products obtained could be easily converted to various chiral ligands via diverse transformations.
Catalytic and stereoselective ortho-lithiation of a ferrocene derivative
Steffen, Patricia,Unkelbach, Christian,Christmann, Mathias,Hiller, Wolf,Strohmann, Carsten
supporting information, p. 9836 - 9840 (2013/09/23)
N,N-Dimethylferrocenylmethylamine can be lithiated stereoselectively by iPrLi in pentane/Et2O using catalytic amounts of the chiral auxiliary (R,R)-TMCDA. In homogenous reactions, high e.r. values were obtained upon crystallization of the lithiated species. The catalytic activity of TMCDA is made possible by its release from the stereomerically pure lithioferrocene as it dimerizes to a homochiral dimeric etherate. Copyright
