127308-98-9 Usage
Uses
Zamifenacin Fumarate is a selective antagonist of mAChR M3 (M3 muscarinic receptor).
Biological Activity
Selective M 3 muscarinic receptor antagonist (pK i values are 8.52, 7.93, 7.90 and 7.78 for M 3 , M 2 , M 1 and M 4 receptors respectively). Displays higher affinity at ileal M 3 receptors (pK i = 9.3) compared to oesophageal and tracheal M 3 receptors (pK i values are 8.8 and 8.2 respectively). In vivo, inhibits gastrointestinal motility in the absence of cardiovascular effects.
Check Digit Verification of cas no
The CAS Registry Mumber 127308-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,3,0 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127308-98:
(8*1)+(7*2)+(6*7)+(5*3)+(4*0)+(3*8)+(2*9)+(1*8)=129
129 % 10 = 9
So 127308-98-9 is a valid CAS Registry Number.
InChI:InChI=1/C27H29NO3.C4H4O4/c1-3-8-22(9-4-1)27(23-10-5-2-6-11-23)31-24-12-7-16-28(19-24)17-15-21-13-14-25-26(18-21)30-20-29-25;5-3(6)1-2-4(7)8/h1-6,8-11,13-14,18,24,27H,7,12,15-17,19-20H2;1-2H,(H,5,6)(H,7,8)/b;2-1+/t24-;/m1./s1
