127309-73-3Relevant academic research and scientific papers
Mild and Stereocontrolled Synthesis of Iodo- and Bromohydrins by X2-Ti(O-i-Pr)4 Opening of Epoxy Alcohols
Alvarez, Eleuterio,Nunez, Maria Teresa,Martin, Victor S.
, p. 3429 - 3431 (2007/10/02)
A mild procedure to obtain halo diols by opening epoxy alcohols with halogen is described.The method is based on the use of Ti(O-i-Pr)4 and the suitable halogen over allylic and homoallylic epoxy alcohols, affording high regioselectivities and yields.Reaction with enantiomerically enriched epoxides leads selectively to chiral halohydrins.
