127321-51-1

Basic information

• Product Name: 7-DIETHYLAMINO-3-HYDROXYMETHYL-4-METHYL-CHROMEN-2-ONE
• Synonyms: 7-DIETHYLAMINO-3-HYDROXYMETHYL-4-METHYL-CHROMEN-2-ONE;CHEMBRDG-BB 5211443;7-(DIETHYLAMINO)-3-(HYDROXYMETHYL)-4-METHYL-2H-CHROMEN-2-ONE;7-(diethylamino)-3-(hydroxymethyl)-4-methyl-2H-chromen-2-one(SALTDATA: FREE)
• CAS NO: 127321-51-1
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.32
• Product Categories: pharmacetical
• Mol File: 127321-51-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 455.7°C at 760 mmHg
• Flash Point: 229.4°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 4.28E-09mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 7-DIETHYLAMINO-3-HYDROXYMETHYL-4-METHYL-CHROMEN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-DIETHYLAMINO-3-HYDROXYMETHYL-4-METHYL-CHROMEN-2-ONE(127321-51-1)
• EPA Substance Registry System: 7-DIETHYLAMINO-3-HYDROXYMETHYL-4-METHYL-CHROMEN-2-ONE(127321-51-1)

Safety Data

• Hazardous Substances Data: 127321-51-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H19NO3/c1-4-16(5-2)11-6-7-12-10(3)13(9-17)15(18)19-14(12)8-11/h6-8,17H,4-5,9H2,1-3H3

Upstream product

• 91-44-1 7-diethylamino-4-methylcoumarin 
• 92295-93-7 3-bromo-7-(diethylamino)-4-methyl-2H-chromen-2-one 
• 27490-33-1 tri-n-butylstannylmethanol 

Downstream Products

• 142730-48-1 3-formyl-4-methyl-7-diethylamino-2-H-benzopyran-2-one 

Relevant articles and documents

BENZOPYRANE AND IMIDAZOLE DERIVATIVES USEFUL FOR THE STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS

In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.