127322-58-1

Upstream product

• 127322-57-0 2-{4-[(Z)-2-[2-(2,2-Dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-1-(tetrahydro-pyran-2-yloxymethyl)-vinyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 127322-57-0 diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate 
• 127322-55-8 2-(Pivaloylamino)-6-<3-(tetrahydropyranyl-2'-oxy)prop-1-ynyl>-4(3H)-oxopyrido<2,3-d>pyrimidine 
• 127322-56-9 2-(Pivaloylamino)-6-<3-(tetrahydropyranyl-2'-oxy)-cis-prop-2-en-1-yl>-4(3H)-oxopyrido<2,3-d>pyrimidine 
• 116387-22-5 2-pivaloylamino-6-bromo-4(3H)-pyrido[2,3-d]pyrimidinone 
• 6089-04-9 3-(tetrahydropyran-2'-yloxy)propyne 
• 159680-66-7 Diethyl N-<4-<1-(tetrahydropyranyl-2'-oxy)-3-(2-(pivaloylamino)-3,4-dihydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)prop-2-en-2-yl>benzoyl>-L-glutamate 

Downstream Products

• 127322-59-2 2-(4-{2-[2-(2,2-Dimethyl-propionylamino)-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl]-1-hydroxymethyl-ethyl}-benzoylamino)-pentanedioic acid diethyl ester 
• 127322-59-2 Diethyl N-<4-<1-hydroxy-3-(2-(pivaloylamino)-3,4-dihydro-4-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)prop-2-yl>benzoyl>-L-glutamate 
• 127322-53-6 2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-1-hydroxymethyl-ethyl]-benzoylamino}-pentanedioic acid 

Relevant academic research and scientific papers

Synthesis of 10-(hydroxymethyl)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid, a potent new analogue of DDATHF (Lometrexol)

A synthesis of 10-(hydroxymethyl)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid [as a mixture of four diastereomers] is described. Substantial cytotoxicity was observed for this new analogue of DDATHF (Lometrexol).

N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives

N-[4-{1-Hydroxy-3-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)prop-2-yl )benzoyl]-glutamic acid, it salts, and derivatives thereof, have an inhibitory effect on one or more enzymes which utilize folic acid and can be used, alone or in