127342-35-2Relevant academic research and scientific papers
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors
Chappie, Thomas A.,Humphrey, John M.,Allen, Martin P.,Estep, Kimberly G.,Fox, Carol B.,Lebel, Lorraine A.,Liras, Spiros,Marr, Eric S.,Menniti, Frank S.,Pandit, Jayvardhan,Schmidt, Christopher J.,Tu, Meihua,Williams, Robert D.,Yang, Feng V.
, p. 182 - 185 (2007)
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal
