1273577-71-1

Basic information

• Product Name: 3-BroMopyrazolo[1,5-a]pyriMidine-6-carboxylic acid
• Synonyms: 3-BroMopyrazolo[1,5-a]pyriMidine-6-carboxylic acid
• CAS NO: 1273577-71-1
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.02956
• Mol File: 1273577-71-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BroMopyrazolo[1,5-a]pyriMidine-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMopyrazolo[1,5-a]pyriMidine-6-carboxylic acid(1273577-71-1)
• EPA Substance Registry System: 3-BroMopyrazolo[1,5-a]pyriMidine-6-carboxylic acid(1273577-71-1)

Safety Data

• Hazardous Substances Data: 1273577-71-1(Hazardous Substances Data)

Usage

Uses

3-Bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid is a useful reactant in the synthesis of BMP inhibitors.

Upstream product

• 933754-38-2 pyrazolo[1,5-α]pyrimidine-6-carboxylic acid 
• 705263-10-1 6-bromo-pyrazolo[1,5-α]pyrimidine 

Relevant articles and documents

Synthetic method for 3-bromopyrazolo[1,5-alpha]pyrimidine-6-formic acid

The invention provides a synthetic method for 3-bromopyrazolo[1,5-alpha]pyrimidine-6-formic acid. The synthetic method comprises the following steps: 3-amino-1H-pyrazole is used as a raw material, the3-amino-1H-pyrazole and 2-bromomalonaldehyde are subjected to condensation to obtain 6-bromo-pyrazolo[1,5-alpha]pyrimidine, the 6-bromo-pyrazolo[1,5-alpha]pyrimidine reacts with PdCl2 and triethylamine to obtain methyl pyrazolo[1,5-alpha]pyrimidine-6-formate, a hydrolysis reaction is performed to obtain pyrazolo[1,5-alpha]pyrimidine-6-formic acid, and finally the pyrazolo[1,5-alpha]pyrimidine-6-formic acid reacts with N-bromosuccinimide to obtain the 3-bromopyrazolo[1,5-alpha]pyrimidine-6-formic acid. The synthetic method for the 3-bromopyrazolo[1,5-alpha]pyrimidine-6-formic acid provided bythe invention has a simple synthetic route, a reasonable process and low costs of the raw materials, is simple, easy to obtain and convenient for operation and post treatment, has a high total yield,does not use a highly-toxic reagent, is easy to amplify, and can be used for large-scale production of the 3-bromopyrazolo[1,5-alpha]pyrimidine-6-formic acid.