127358-11-6

Basic information

• Product Name: (3R,5R,6S)-4-(tert-Butoxycarbonyl)-5,6-diphenyl-3-(1'-naphthyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one
• Synonyms: (3R,5R,6S)-4-(tert-Butoxycarbonyl)-5,6-diphenyl-3-(1'-naphthyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one
• CAS NO: 127358-11-6
• Molecular Weight: 479.576
• Mol File: 127358-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,5R,6S)-4-(tert-Butoxycarbonyl)-5,6-diphenyl-3-(1'-naphthyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5R,6S)-4-(tert-Butoxycarbonyl)-5,6-diphenyl-3-(1'-naphthyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one(127358-11-6)
• EPA Substance Registry System: (3R,5R,6S)-4-(tert-Butoxycarbonyl)-5,6-diphenyl-3-(1'-naphthyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one(127358-11-6)

Safety Data

• Hazardous Substances Data: 127358-11-6(Hazardous Substances Data)

Upstream product

• 127420-01-3 (3R,5R,6S)-3-Bromo-4-(tert-butoxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-1,4-oxazin-2-one 

Downstream Products

• 100896-07-9 (R)-α-(1-naphthyl)glycine 
• 111820-05-4 (S)-amino(naphthalen-1-yl)acetic acid 
• 127358-21-8 N-(Benzyloxycarbonyl)-D-naphthylglycine 
• 127358-18-3 (3R,5R,6S)-5,6-Diphenyl-3-(1'-naphthyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one 

Relevant articles and documents

Asymmetric synthesis of arylglycines

The asymmetric synthesis of several arylglycines are reported. The methodology deployed involves either cuprate or Friedel - Crafts couplings to chiral bromoglycinates. The % ee's range from 82 to 94%. Both an oxidative and reductive protocol are employed to unmask the oxazinone chiral auxilliary providing the free α-amino acids.