127378-16-9Relevant academic research and scientific papers
Rhodanine derivatives as novel inhibitors of PDE4
Irvine, Mark W.,Patrick, Graham L.,Kewney, Justin,Hastings, Stuart F.,MacKenzie, Simon J.
, p. 2032 - 2037 (2008/12/21)
The discovery, synthesis and in vitro activity of a novel series of rhodanine based phosphodiesterase-4 (PDE4) inhibitors is described. Structure-activity relationship studies directed toward improving potency led to the development of submicromolar inhibitors 2n and 3i (IC50 = 0.89 & 0.74 μM). The replacement of rhodanine with structurally related heterocycles was also investigated and led to the synthesis of pseudothiohydantoin 7 (IC50 = 0.31 μM).
