127380-43-2Relevant academic research and scientific papers
Synthesis of Dihydro-1H-indenes via a Formal 3 + 2 Cycloaddition of p-Quinone Methides and Styrenes
Angle, Steven R.,Arnaiz, Damian O.
, p. 3708 - 3710 (1990)
The synthesis of dihydro-1H-indenes via the formal 3 + 2 cycloaddition of an electron-rich alkene and a p-quinone methide is reported.
Formal Cycloaddition of Benzylic Cations with Alkenes
Angle, Steven R.,Arnaiz, Damian O.
, p. 5937 - 5947 (2007/10/02)
The reaction of benzylic cations with styrenes affords dihydro(1H)indenes in good yield via a formal atom cycloadditon.The cations were generated from quinone methides and benzylic alcohols. (E)-Styrenes participate in the reaction with remarkable stereoselectivity affording dihydro(1H)indenes with three stereogenic centers with >40:1 diastereoselectivity.A possible transition state for the reaction is discussed.Less activated alkenes such as dihydropyran and methylcyclohexane afforded cycloadducts in 66percent and 51percent yields, respectively.
