127394-13-2

Upstream product

• 26152-25-0 methyl 1-(thiophene-2-ylmethylene)-hydrazinecarbodithioate 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 198222-53-6 VO(C₁₂H₁₀N₃S₂Cl)2⁽²⁺⁾*SO₄^(2-)=[VO(C₁₂H₁₀N₃S₂Cl)2]SO₄ 
• 198222-51-4 VO(C₁₂H₉N₃S₂Cl)2 

Relevant academic research and scientific papers

Synthesis and Ribonucleotide reductase inhibitory activity of thiosemicarbazones

Ribonucleotide reductase (RR) is an important therapeutic target for anticancer drugs. The structure of human RR features a 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2. Prokaryotically expressed and highly purified recombinant human RR subunits, hRRM1 and hRRM2, were used for holoenzyme-based [3H]CDP reduction in vitro assay. Ten new thiosemicarbazones (7-16) were synthesized and screened for their RR inhibitory activity. Two thiosemicarbazones derived from p-hydroxy benzaldehyde (9 and 10) were found to be active but less potent than the standard, Hydroxyurea (HU). Guided by the activity of compounds 9 and 10, 11 new thiosemicarbazones (17-27) derived from p-hydroxy benzaldehyde were prepared and screened for their RR inhibitory activity. All the 11 compounds were more potent than HU.