127408-30-4

Basic information

• Product Name: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE
• Synonyms: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE;Y-27152
• CAS NO: 127408-30-4
• Molecular Formula: C21H22N2O4
• Molecular Weight: 366.41038
• Product Categories: Potassium channel
• Mol File: 127408-30-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 513.4°Cat760mmHg
• Flash Point: 264.3°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 2.29E-11mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Store at RT
• PKA: 13.18±0.60(Predicted)
• CAS DataBase Reference: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE(127408-30-4)
• EPA Substance Registry System: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE(127408-30-4)

Safety Data

• Hazardous Substances Data: 127408-30-4(Hazardous Substances Data)

Usage

Uses

Y-27152, is a prodrug of the Kir6 (KATP) channel opener. It has also shown to produce antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Biological Activity

Prodrug of the K ATP channel opener Y-26763 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide ). Inactive in vitro ; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. In vivo, produces long-lasting antihypertensive effects with minimal tachycardia following oral administration in hypertensive animals.

InChI:InChI=1/C21H22N2O4/c1-14(24)23(26-13-15-7-5-4-6-8-15)19-17-11-16(12-22)9-10-18(17)27-21(2,3)20(19)25/h4-11,19-20,25H,13H2,1-3H3/t19-,20+/m1/s1