127437-44-9

Basic information

• Product Name: 6-Chloropyridine-2,3-dicarboxylic acid
• Synonyms: 6-Chloropyridine-2,3-dicarboxylic acid;6-Chloro-2,3-pyridinedicarboxylic acid
• CAS NO: 127437-44-9
• Molecular Formula: C7H4ClNO4
• Molecular Weight: 201.56396
• Mol File: 127437-44-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 445.1 °C at 760 mmHg
• Flash Point: 223 °C
• Appearance: /
• Density: 1.684 g/cm³
• Vapor Pressure: 1.05E-08mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-Chloropyridine-2,3-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyridine-2,3-dicarboxylic acid(127437-44-9)
• EPA Substance Registry System: 6-Chloropyridine-2,3-dicarboxylic acid(127437-44-9)

Safety Data

• Hazardous Substances Data: 127437-44-9(Hazardous Substances Data)

Usage

Uses

6-Chloropyridine-2,3-dicarboxylic acid is a useful research chemical.

InChI:InChI=1/C7H4ClNO4/c8-4-2-1-3(6(10)11)5(9-4)7(12)13/h1-2H,(H,10,11)(H,12,13)

Upstream product

• 612-62-4 2-Chloroquinoline 

Downstream Products

• 32383-03-2 6-chloropyridine-2,3-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Integrase inhibitor compounds

Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.

Oxidation of 2- and 3-Halogenated Quinolines: An Easy Access to 5- and 6-Halogenopyridine-2,3-dicarboxylic Acids

Pyridine-2,3-dicarboxylic acids bearing an halogen in the position α or β to the nitrogen atom were synthesized by oxidation of the corresponding quinolines. Two methods, using either ozone followed by hydrogen peroxide or ruthenium tetroxide under catalytic conditions were used. Diacids 1b,c and 2a-c substituted in 6-position by a chlorine or bromine and in 5-position by a fluorine, chlorine or bromine, respectively, were isolated in yields ranging from 46-71 percent. Yields of 6-fluoro and 6- or 5-iodo diacids 1a,d and 2d did not exceed 30 percent.