127460-04-2

Basic information

• Product Name: N-(4-hydroxyphenyl)-2-(4-isobutylphenyl)propanamide
• Synonyms: N-(4-hydroxyphenyl)-2-(4-isobutylphenyl)propanamide
• CAS NO: 127460-04-2
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.39142
• Mol File: 127460-04-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-hydroxyphenyl)-2-(4-isobutylphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxyphenyl)-2-(4-isobutylphenyl)propanamide(127460-04-2)
• EPA Substance Registry System: N-(4-hydroxyphenyl)-2-(4-isobutylphenyl)propanamide(127460-04-2)

Safety Data

• Hazardous Substances Data: 127460-04-2(Hazardous Substances Data)

Upstream product

• 123-30-8 4-amino-phenol 
• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 
• 15687-27-1 ibuprofen 
• 201230-82-2 carbon monoxide 
• 63444-56-4 p-isobutylstyrene 

Relevant articles and documents

Aryl phenol compound as well as synthesis method and application thereof

The invention discloses a synthesis method of an aryl phenol compound shown as a formula (3). All systems are carried out in an air or nitrogen atmosphere, and visible light is utilized to excite a photosensitizer for catalyzation. In a reaction solvent, ArNR1R2 as shown in a formula (1) and water as shown in a formula (2) are used as reaction raw materials and react under the auxiliary action of acid to obtain the aryl phenol compound as shown in a formula (3). The ArNR1R2 in the formula (1) can be primary amine and tertiary amine, can also be steroid and amino acid derivatives, and can also be drugs or derivatives of propofol, paracetamol, ibuprofen, oxaprozin, indomethacin and the like. The synthesis method has the advantages of cheap and easily available raw materials, simple reaction operation, mild reaction conditions, high reaction yield and good compatibility of substrate functional groups. The fluid reaction not only can realize amplification of basic chemicals, but also can realize amplification of fine chemicals, such as synthesis of drugs propofol and paracetamol. The invention has wide application prospect and use value.

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen

Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX) inhib