127477-09-2

Upstream product

• 127477-25-2 3-(1-phenyl-1,4-dihydro-indeno<1,2-c>pyrazol-3-yl)-3-oxo-propanenitrile 
• 2909-38-8 m-chlorophenyl isocyanate 
• 83-33-0 inden-1-one 
• 100397-38-4 ethyl β-(1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate 
• 56456-85-0 1,4-Dihydro-1-phenyl-indeno[1,2-c]pyrazole-3-carboxylic acid,ethyl ester 

Relevant academic research and scientific papers

Condensed pyrazole 3-oxo-propanenitrile derivatives

Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents a --CH(R4)-- group, an oxygen atom or a --S(O)n -- group where n is 0, 1 or 2; R1 represents C1 -C6 alkyl,

Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents an oxygen atom or a --CH(R4)--, --O--CH(R4)--, --S(O)n --CH(R4)--, --CH(R4)--O--, --CH(R4)--S(O)n -- --CH(R4)--CH2 -- group wherein n is 0, 1 or 2; R1 represents C1 -C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3, and R4 are as herein defined; and Q is hydrogen, carboxy, C2 -C7 -alkoxycarbonyl or a --CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

Use of heteroaryl-3-oxo-propanenitrile derivatives in treating clinical wherein myelopoiesis suppression occurs

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents an oxygen atom or a --CH(R4)--, --O--CH(R4)--,--S(O)n --, --S(O)n --CH(R4)--, --CH(R4)--O--, --CH(R4)--S(O)n -- or --CH(R4)--CH2 -- group wherein n is 0, 1 or 2; R1 represents C1 --C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3 and R4 are as herein defined; and Q is hydrogen, carboxy, C2 -C7 - alkoxycarbonyl or a --CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in stimulating myelopoiesis in bone marrow suppressed mammals.