1274835-99-2

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 1274835-94-7 (+)-(R)-2-benzyloxy-3,3,3-trifluoro-2-phenyl-N-tosylpropylamine 
• 1274835-92-5 C₂₃H₂₀F₃NO₃S 
• 1274836-02-0 (-)-(S)-2-phenyl-N-tosyl-2-trifluoromethylaziridine 
• 1274835-90-3 C₁₆H₁₃F₃O₂ 

Downstream Products

• 1274836-02-0 (-)-(S)-2-phenyl-N-tosyl-2-trifluoromethylaziridine 
• 1274836-11-1 (+)-(S)-3,3,3-trifluoro-2-phenyl-2-tosylaminopropan-1-ol 
• 1274836-15-5 (+)-(S)-N-benzyl-3,3,3-trifluoro-2-phenyl-2-tosylaminopropylamine 
• 1274836-18-8 (+)-(1S,1'R)-N-[(1'-phenyl)ethyl]-3,3,3-trifluoro-2-phenyl-2-tosylaminopropylamine 
• 1274836-21-3 (+)-(S)-1,1,1-trifluoro-3-morpholin-4-yl-2-phenyl-N-tosylpropan-2-amine 
• 1274836-25-7 (-)-(S)-3,3,3-trifluoro-N,2-diphenyl-2-tosylaminopropylamine 
• 1274836-28-0 (-)-(S)-3,3,3-trifluoro-2-phenyl-2-tosylamino-N-tosylpropylamine 

Relevant academic research and scientific papers

Enantiomerically pure 2-aryl(alkyl)-2-trifluoromethylaziridines: Synthesis and ring opening with selected O- and N-nucleophiles

We report herein the synthesis of enantiomerically pure 2-phenyl- and 2-ethyl-2-trifluoromethylaziridines by Mitsunobu-type cyclisation of the corresponding N-protected amino alcohols, and our results regarding their ring opening with selected nucleophiles. Under basic conditions, N-tosyl aziridines have been regioselectively opened at the less hindered carbon. Under acidic conditions, the regioselectivity of the attack depends on the nature of the substituent at C-2 and on the nitrogen protecting group.