1274906-19-2Relevant academic research and scientific papers
On the formation of seven-membered rings by arene-ynamide cyclization
Brutiu, Bogdan R.,Bubeneck, Wilhelm Andrei,Cvetkovic, Olivera,Li, Jing,Maulide, Nuno
, p. 3 - 10 (2019)
Abstract: A Br?nsted acid-catalyzed selective arene-ynamide cyclization is described. This reaction proceeds via a keteniminium intermediate and enables the preparation of seven-membered ring enamide products. Mechanistic studies uncover an unusual product inhibition behavior. Graphical abstract: [Figure not available: see fulltext.].
Hydrative Aminoxylation of Ynamides: One Reaction, Two Mechanisms
Pinto, Alexandre,Kaiser, Daniel,Maryasin, Boris,Di Mauro, Giovanni,González, Leticia,Maulide, Nuno
supporting information, p. 2515 - 2519 (2018/02/06)
Organic synthesis boasts a wide array of reactions involving either radical species or ionic intermediates. The combination of radical and polar species, however, has not been explored to a comparable extent. Herein we present the hydrative aminoxylation
Formation of α-chalcogenyl acrylamides through unprecedented chalcogen-mediated metal-free oxyfunctionalization of ynamides with DMSO as an oxidant
Huang, Hai,Tang, Luning,Liu, Qi,Xi, Yang,He, Guangke,Zhu, Hongjun
supporting information, p. 5605 - 5608 (2016/05/09)
A novel chalcogen-mediated oxyfunctionalization mode of ynamides for the synthesis of α-chalcogenyl acrylamides has been developed. Independent of metal catalysts, external oxidants and additives, this mild process afforded a range of structurally diverse
A Bronsted acid catalyzed redox arylation
Peng, Bo,Huang, Xueliang,Xie, Lan-Gui,Maulide, Nuno
supporting information, p. 8718 - 8721 (2014/08/18)
A Bronsted acid catalyzed redox arylation of ynamides that employs aryl sulfoxides as the arylating agents is reported. This metal-free transformation proceeds at room temperature and efficiently affords α-arylated oxazolidinones in a redox-neutral, atom-
Gold-catalyzed nitrene transfer to activated alkynes: Formation of α,β-unsaturated amidines
Li, Chaoqun,Zhang, Liming
supporting information; experimental part, p. 1738 - 1741 (2011/05/11)
A gold-catalyzed intermolecular nitrene transfer to alkynes was developed for the first time, revealing a new mode of nitrene transfer and providing a novel access to versatile α-imino metal carbenes. Various mild nitrene-transfer reagents were examined, and iminopyridium ylides especially those based on 3,5-dichloropyridine proved be highly effective. With activated alkynes such as N-alkynyloxazolidinones as substrates, α,β- unsaturated amidines were formed in mostly good yields.
