1274933-95-7

Basic information

• Product Name: 4-(2-hydroxy-phenyl)-piperidin-4-ol hydrochloride
• Synonyms: 4-(2-hydroxy-phenyl)-piperidin-4-ol hydrochloride
• CAS NO: 1274933-95-7
• Molecular Weight: 229.707
• Mol File: 1274933-95-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-hydroxy-phenyl)-piperidin-4-ol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxy-phenyl)-piperidin-4-ol hydrochloride(1274933-95-7)
• EPA Substance Registry System: 4-(2-hydroxy-phenyl)-piperidin-4-ol hydrochloride(1274933-95-7)

Safety Data

• Hazardous Substances Data: 1274933-95-7(Hazardous Substances Data)

Upstream product

• 336882-79-2 1-benzyl-4-(2-benzyloxy-phenyl)-piperidin-4-ol 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 328000-16-4 (2-(benzyloxy)phenyl)magnesium bromide 

Relevant articles and documents

(4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain (4-phenyl-piperidin-1-yl)- [5-(1 H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds that, inter alia, inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 1 1 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.