127517-01-5Relevant academic research and scientific papers
A Formal Synthesis of FK-506. Exploration of Some Alternatives to Macrolactamization
Jones, A. Brian,Villalobos, Annabella,Linde, Robert G.,Danishefsky, Samuel J.
, p. 2786 - 2797 (2007/10/02)
The coupling of the previously described subunits 2, 3, and 4 is described.The C28-C27 E-double bond is fashioned from a sulfurane induced dehydration of alcohol 11.The C19-C20 E-double bond was constructed via a modified Julia process culminating in a reductive elimination of a vicinal trifluoroacetoxy sulfone (see 22 -> 23 -> 24 and 25).The synthesis of intermediates anticipating potential macrolactonization are also described.
