127517-38-8 Usage
Classification
Nucleoside analog
A chemical compound that resembles a natural nucleoside
Original purpose
Antiretroviral medication
Developed to treat HIV/AIDS
Mechanism of action
Inhibition of reverse transcriptase enzyme
Essential for the replication of the HIV virus
Potency
Potent inhibitor of viral replication
Effective in slowing down the spread of HIV
Usage
Component of highly active antiretroviral therapy (HAART)
A treatment regimen for HIV patients
Side effects
Anemia and bone marrow suppression
Negative impacts on the blood and bone marrow
Resistance
Can develop over time
The virus may become less susceptible to AZT
Importance
Remains a key component of HIV treatment regimens
Despite limitations and potential resistance
Considerations
Limitations and potential for resistance must be taken into account
Alternative antiretroviral medications may be needed
Check Digit Verification of cas no
The CAS Registry Mumber 127517-38-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,5,1 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127517-38:
(8*1)+(7*2)+(6*7)+(5*5)+(4*1)+(3*7)+(2*3)+(1*8)=128
128 % 10 = 8
So 127517-38-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N5O4/c1-15-3-5(9(17)12-10(15)18)7-2-6(13-14-11)8(4-16)19-7/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
127517-38-8Relevant articles and documents
Synthesis of 1-methyl-5-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)uracil and 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)uracil. The C-nucleoside isostere of 3'-azido-3'-deoxythymidine and its 2'-'up'-fluoro analogue
Sochacka,Nawrot,Pankiewicz,Watanabe
, p. 1995 - 1999 (2007/10/02)
1-Methyl-5-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)uracil (C-AZT), a C-nucleoside isostere of the potent anti-AIDS nucleoside 3'-azido-3'-deoxythymidine (AZT), was synthesized. 1-Methyl-2'-deoxy-5'-O-tritylpseudouridine (2a) was oxidized with CrO
