127517-43-5

Basic information

• Product Name: 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil
• Synonyms: 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil
• CAS NO: 127517-43-5
• Molecular Formula: C10H12 F N5 O4
• Molecular Weight: 285.2318
• Mol File: 127517-43-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil(127517-43-5)
• EPA Substance Registry System: 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil(127517-43-5)

Safety Data

• Hazardous Substances Data: 127517-43-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12FN5O4/c1-16-2-4(9(18)13-10(16)19)8-6(11)7(14-15-12)5(3-17)20-8/h2,5-8,17H,3H2,1H3,(H,13,18,19)/t5-,6-,7-,8+/m1/s1

Upstream product

• 127517-39-9 1-methyl-5-(2-deoxy-2-fluoro-5-O-trityl-β-D-arabinofuranosyl)uracil 
• 127517-40-2 1-methyl-5-(2-deoxy-2-fluoro-5-O-trityl-β-D-lyxofuranosyl)uracil 
• 127517-41-3 Methanesulfonic acid (2R,3S,4R,5S)-4-fluoro-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 110419-25-5 1-methyl-5-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil 
• 127517-42-4 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-5-O-trityl-β-D-arabinofuranosyl)uracil 

Relevant articles and documents

Synthesis of 1-methyl-5-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)uracil and 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)uracil. The C-nucleoside isostere of 3'-azido-3'-deoxythymidine and its 2'-'up'-fluoro analogue

1-Methyl-5-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)uracil (C-AZT), a C-nucleoside isostere of the potent anti-AIDS nucleoside 3'-azido-3'-deoxythymidine (AZT), was synthesized. 1-Methyl-2'-deoxy-5'-O-tritylpseudouridine (2a) was oxidized with CrO