127517-73-1

Basic information

• Product Name: 5-amino-4-chloro-6-<<1-(3-nitrophenyl)ethyl>amino>pyrimidine
• Synonyms: 5-amino-4-chloro-6-<<1-(3-nitrophenyl)ethyl>amino>pyrimidine
• CAS NO: 127517-73-1
• Molecular Weight: 293.713
• Mol File: 127517-73-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-amino-4-chloro-6-<<1-(3-nitrophenyl)ethyl>amino>pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-4-chloro-6-<<1-(3-nitrophenyl)ethyl>amino>pyrimidine(127517-73-1)
• EPA Substance Registry System: 5-amino-4-chloro-6-<<1-(3-nitrophenyl)ethyl>amino>pyrimidine(127517-73-1)

Safety Data

• Hazardous Substances Data: 127517-73-1(Hazardous Substances Data)

Upstream product

• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 90271-37-7 3-nitro-α-methylbenzylamine 
• 121-89-1 3-Nitroacetophenone 

Downstream Products

• 127517-64-0 9-<1-(3-aminophenyl)ethyl>-6-(dimethylamino)-9H-purine 
• 127517-77-5 6-(dimethylamino)-9-<1-(3-nitrophenyl)ethyl>-9H-purine 
• 127517-75-3 6-chloro-9-<1-(3-nitrophenyl)ethyl>-9H-purine 

Relevant articles and documents

Benzodiazepine Receptor Binding Activity of 9-(1-Phenylethyl)purines

Several α-methyl analogues of the 9-benzylpurines that bind to the benzodiazepine receptor (BZR) were synthesized and tested for BZR-binding activity.Although introduction of a m-amino group and an 8-bromo substituent gave an additive increase in BZR affinity with 9-(3-aminobenzyl)-8-bromo-6-(dimethylamino)-9H-purine (4), addition of an α-methyl group to 4 resulted in loss in BZR affinity.This loss in affinity is apparently due to repulsive, steric interactions between the 8-bromo and 9-(1-phenylethyl) substituents, which results in a conformation that is not optimal for interaction with the BZR.Several compounds were tested on a modified Geller-Seifter conflict schedule, but none exhibited significant anxiolytic activity.