127519-22-6

Basic information

• Product Name: ethyl {2-amino-6-[(4-chlorobenzyl)amino]pyridin-3-yl}carbamate dihydrochloride
• CAS NO: 127519-22-6
• Molecular Formula: C₁₅H₁₉Cl₃N₄O₂
• Molecular Weight: 393.696
• Mol File: 127519-22-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 455.9°C at 760 mmHg
• Flash Point: 229.5°C
• Vapor Pressure: 1.69E-08mmHg at 25°C
• CAS DataBase Reference: ethyl {2-amino-6-[(4-chlorobenzyl)amino]pyridin-3-yl}carbamate dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl {2-amino-6-[(4-chlorobenzyl)amino]pyridin-3-yl}carbamate dihydrochloride(127519-22-6)
• EPA Substance Registry System: ethyl {2-amino-6-[(4-chlorobenzyl)amino]pyridin-3-yl}carbamate dihydrochloride(127519-22-6)

Safety Data

• Hazardous Substances Data: 127519-22-6(Hazardous Substances Data)

Upstream product

• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 157840-45-4 N₂-(4-chlorobenzyl)-5-nitropyridine-2,6-diamine 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 541-41-3 chloroformic acid ethyl ester 
• 1027594-02-0 N₂-(4-chlorobenzyl)pyridine-2,5,6-triamine 

Relevant articles and documents

Synthesis and quantitative structure-activity relationships of anticonvulsant 2,3,6-triaminopyridines

The synthesis of 2,3,6-triaminopyridine derivatives, representing a unique chemical structure for anticonvulsants, is described. The synthetic program was performed (a) to identify more potent analogs, (b) to determine structural properties controlling potency as well as neurotoxicity, and (c) to reduce the requirements for animal testing. As a result, besides other structural properties, the overall molecular lipophilicity (log k', octanol- coated column) explained changes in anticonvulsant potency and neurotoxicity. Mimicking the interaction of the amphiphilic triaminopyridines with biological membranes, NMR experiments in the presence of lecithin vesicles were conducted in order to measure the phospholipid-binding parameter log Δ(1/T2). Replacement of log k' with log Δ(1/T2) in the correlation analysis afforded a more significant equation describing the anticonvulsant activity of 21 derivatives.