127557-08-8

Basic information

• Product Name: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
• Synonyms: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one;3,4-Dihydro-9-Methoxy-1-benzoxepin-5(2H)-one
• CAS NO: 127557-08-8
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Mol File: 127557-08-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one(127557-08-8)
• EPA Substance Registry System: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one(127557-08-8)

Safety Data

• Hazardous Substances Data: 127557-08-8(Hazardous Substances Data)

Usage

General Description

9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one is a chemical compound with the molecular formula C11H10O3. As its name indicates, it is a benzoxepin derivative, which is a seven-membered heterocyclic compound containing an oxygen atom. The presence of the methoxy group and the ketone functional group contributes to the chemical behavior of this compound. Further details such as its physical properties, toxicity, and potential applications in various industries such as pharmaceuticals, material science, or synthetic chemistry require more specific study and cannot be inferred just from its structure.

Upstream product

• 90-05-1 2-methoxy-phenol 
• 104215-93-2 4-(2-methoxyphenoxy)butanoic acid 
• 127557-20-4 4-(2-carboxy-6-methoxyphenoxy)butanoic acid diethyl ester 
• 35030-98-9 ethyl 2-hydroxy-3-methoxybenzoate 
• 127557-25-9 2,3,4,5-tetrahydro-9-methoxy-5-oxo-1-benzoxepin-4-carboxylic acid ethyl ester 

Relevant articles and documents

Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder

The structure-activity relationship of a series of tricyclic-sulfonamide compounds 11-32 culminating in the discovery of N-[trans-4-(4,5-dihydro-3,6- dithia-1-aza-benzo[e]azulen-2-ylamino)-cyclohexylmethyl]-methanesulfonamide (15, Lu AA33810) is reported. Compound 15 was identified as a selective and high affinity NPY5 antagonist with good oral bioavailability in mice (42%) and rats (92%). Dose dependent inhibition of feeding was observed after i.c.v. injection of the selective NPY5 agonist ([cPP1-7,NPY19-23,Ala 31,Aib32,Gln34]-hPP). In addition, ip administration of Lu AA33810 (10 mg/kg) produced antidepressant-like effects in a rat model of chronic mild stress.