127560-92-3

Basic information

• Product Name: (R,S)-4-benzylamino-4,5-dihydro-2(3H)-furanone
• Synonyms: (R,S)-4-benzylamino-4,5-dihydro-2(3H)-furanone
• CAS NO: 127560-92-3
• Molecular Weight: 191.23
• Mol File: 127560-92-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R,S)-4-benzylamino-4,5-dihydro-2(3H)-furanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-4-benzylamino-4,5-dihydro-2(3H)-furanone(127560-92-3)
• EPA Substance Registry System: (R,S)-4-benzylamino-4,5-dihydro-2(3H)-furanone(127560-92-3)

Safety Data

• Hazardous Substances Data: 127560-92-3(Hazardous Substances Data)

Upstream product

• 497-23-4 2-buten-4-olide 
• 100-46-9 benzylamine 
• 157036-95-8 1-Benzyl-5-hydroxymethyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 152580-30-8 (+/-)-4-Amino-4,5-dihydro-2(3H)-furanone 
• 335265-63-9 (R,S)-4-benzylamino-3,3-diallyl-4,5-dihydro-2(3H)-furanone 
• 206348-65-4 3(S)-[(t-butoxycarbonyl)amino]-γ-butyrolactone 

Relevant articles and documents

A new approach to the synthesis of functionalized pyrido[2,3-b]indoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C- 9a positions

The enolate of 4-N-(tert-butyloxycarbonyl)aminobutyro-γ-lactone 9 reacted with 2-bromo-1methylindole-3-carboxaldehyde in the presence of stannic chloride to give the product of aldol condensation 16. Deprotection and dehydration of the latter with trifluo

N-substituted 4-amino-3,3-dipropyl-2(3H)-furanones: New positive allosteric modulators of the GABAA receptor sharing electrophysiological properties with the anticonvulsant loreclezole

1,4-Addition of benzylamine to 2(5H)-furanone followed by dialkylation of the 3-position with allylbromide gave (±)-4-benzyl-3,3-diallyl-2(3H)-furanone (8), which served as the intermediate for the synthesis of various N-substituted 4-amino-3,3-dipropyl-2

ASYMMETRIC 1,4-ADDITIONS TO 5-ALKOXY-2(5H)-FURANONES ENANTIOSELECTIVE SYNTHESIS AND ABSOLUTE CONFIGURATION DETERMINATION OF β-AMINO-γ-BUTYROLACTONES AND AMINO DIOLS

The synthesis of enantiomerically pure β-amino-γ-butyrolactones via asymmetric conjugate addition of various amines to 5-methyloxy-2(5H)-furanone is described.This route provides access to new multifunctional homochiral building blocks.The absolute configuration of the β-amino-γ-butyrolactones is established by X-ray analysis and 1H NMR correlation.The conjugate addition of amines to 2(5H)-furanone, 5-alkyl-2(5H)-furanones and 5-alkoxy-2(5H)-furanones was studied and an enhanced reactivity was observed in 2(5H)-furanones due to a γ-alkoxy-effect.The synthetic utility of the asymmetric amine addition is illustrated in an efficient route to various optically pure 2-amino-1,4-butanediols.