1275607-95-8

Basic information

• Product Name: 6-ethyl-2-mercapto-7H-pyrrolo[2,3- d]pyrimidin-4-ol
• Synonyms: 6-ethyl-2-mercapto-7H-pyrrolo[2,3- d]pyrimidin-4-ol
• CAS NO: 1275607-95-8
• Molecular Formula: C8H9N3OS
• Molecular Weight: 195.24156
• Mol File: 1275607-95-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.46±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.70±0.20(Predicted)
• CAS DataBase Reference: 6-ethyl-2-mercapto-7H-pyrrolo[2,3- d]pyrimidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethyl-2-mercapto-7H-pyrrolo[2,3- d]pyrimidin-4-ol(1275607-95-8)
• EPA Substance Registry System: 6-ethyl-2-mercapto-7H-pyrrolo[2,3- d]pyrimidin-4-ol(1275607-95-8)

Safety Data

• Hazardous Substances Data: 1275607-95-8(Hazardous Substances Data)

Usage

General Description

6-ethyl-2-mercapto-7H-pyrrolo[2,3-d]pyrimidin-4-ol is a chemical compound with the molecular formula C9H10N4OS. It is a heterocyclic organic compound that contains a pyrrolopyrimidine ring. The compound features an ethyl group at the 6th position, a mercapto group at the 2nd position, and a hydroxyl group at the 4th position of the pyrrolopyrimidine ring. It is used in organic synthesis and medicinal chemistry research, and it may have potential applications in drug development due to its unique structure and properties. The compound's structure and functional groups make it an interesting target for further study and potential pharmaceutical development. However, its specific uses and properties may vary depending on its intended applications in different fields of chemistry and biology.

Upstream product

• 67722-35-4 2-Cyano-4-oxo-hexanoic acid methyl ester 
• 253332-14-8 6-amino-5-(2-ethyl-1,3-dioxolan-2-ylmethyl)-2-thiouracil 
• 1425309-53-0 C₁₀H₁₅NO₄ 
• 253332-14-8 6-amino-5-[(2-ethyl-1,3-dioxolan-2-yl)methyl]-2-sulfanylpyrimidin-4-ol 
• 253332-12-6 α-cyano-2-ethyl-1,3-dioxolane-2-propanoic acid ethyl ester 

Downstream Products

• 253332-18-2 C₉H₁₁N₃OS 
• 1275607-71-0 4-ethoxy-6-ethyl-2-(methylthio)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1275607-72-1 4-ethoxy-6-ethyl-2-(methylsulfonyl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1275608-08-6 4-ethoxy-6-ethyl-7-(phenylsulfonyl)-N-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 

Relevant articles and documents

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication. The high degree of conservation in the ATP-binding pockets of these enzymes make them appealing targets for broad-spectrum inhibitor development. A pyrrolopyrimidine scaffold was identified from a pharmacophore-based fragment screen with optimization potential. Structural characterization of inhibitor complexes conducted using selected GyrB/ParE orthologs aided in the identification of important steric, dynamic and compositional differences in the ATP-binding pockets of the targets, enabling the design of highly potent pyrrolopyrimidine inhibitors with broad enzymatic spectrum and dual targeting activity.