1275608-17-7 Usage
Description
2,4-dichloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidine is a pyrrolopyrimidine derivative, a chemical compound with the molecular formula C8H7Cl2N3. It is recognized for its potential as a building block in the synthesis of pharmaceutical and agrochemical compounds, particularly due to its ability to selectively inhibit specific enzymes and receptors. This characteristic positions it as a promising candidate in medicinal chemistry for the development of novel drug candidates, including those for cancer treatment and other therapeutic applications.
Uses
Used in Pharmaceutical Industry:
2,4-dichloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to selectively target enzymes and receptors. Its role in the development of cancer treatment drugs is particularly noteworthy, as it can contribute to the creation of more effective and targeted therapies.
Used in Agrochemical Industry:
In the agrochemical field, 2,4-dichloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidine is utilized as a precursor in the production of compounds that can address specific agricultural needs, such as pest control or crop protection, by selectively interacting with biological targets.
Used in Medicinal Chemistry Research:
2,4-dichloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidine serves as a valuable component in medicinal chemistry research, where it is employed to explore and develop new drug candidates with potential therapeutic benefits. Its structural properties allow for the design of molecules that can interact with biological targets in unique ways, leading to innovative treatments.
It is crucial to handle 2,4-dichloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidine with care, adhering to proper safety guidelines and protocols to mitigate any potential health hazards associated with its use in research and development settings.
Check Digit Verification of cas no
The CAS Registry Mumber 1275608-17-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,5,6,0 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1275608-17:
(9*1)+(8*2)+(7*7)+(6*5)+(5*6)+(4*0)+(3*8)+(2*1)+(1*7)=167
167 % 10 = 7
So 1275608-17-7 is a valid CAS Registry Number.
1275608-17-7Relevant articles and documents
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
Tari, Leslie W.,Trzoss, Michael,Bensen, Daniel C.,Li, Xiaoming,Chen, Zhiyong,Lam, Thanh,Zhang, Junhu,Creighton, Christopher J.,Cunningham, Mark L.,Kwan, Bryan,Stidham, Mark,Shaw, Karen J.,Lightstone, Felice C.,Wong, Sergio E.,Nguyen, Toan B.,Nix, Jay,Finn, John
, p. 1529 - 1536 (2013/03/14)
The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication. The high degree of conservation in the ATP-binding pockets of these enzymes make them appealing targets for broad-spectrum inhibitor development. A pyrrolopyrimidine scaffold was identified from a pharmacophore-based fragment screen with optimization potential. Structural characterization of inhibitor complexes conducted using selected GyrB/ParE orthologs aided in the identification of important steric, dynamic and compositional differences in the ATP-binding pockets of the targets, enabling the design of highly potent pyrrolopyrimidine inhibitors with broad enzymatic spectrum and dual targeting activity.
