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127561-10-8

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127561-10-8 Usage

General Description

"1H-INDOLE,3-(2-BROMOETHYL)-5-FLUORO-" is a chemical compound with the molecular formula C11H10BrFN2. It contains an indole ring with a 2-bromoethyl and 5-fluoro substituents. 1H-INDOLE,3-(2-BROMOETHYL)-5-FLUORO- is used in organic synthesis and pharmaceutical research, where it may be used as a building block for the synthesis of other compounds or as a potential drug candidate. Its specific properties and potential biological activities are areas of ongoing research and investigation. This chemical has the potential to be used in the development of new drugs with therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 127561-10-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,5,6 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 127561-10:
(8*1)+(7*2)+(6*7)+(5*5)+(4*6)+(3*1)+(2*1)+(1*0)=118
118 % 10 = 8
So 127561-10-8 is a valid CAS Registry Number.

127561-10-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(5-fluoro-1H-indol-3-yl)ethyl bromide

1.2 Other means of identification

Product number -
Other names 3-(2-bromoethyl)-5-fluoro-1H-indole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127561-10-8 SDS

127561-10-8Relevant articles and documents

Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT1A/5-HT7

Gu, Zheng-Song,Wang, Wen-Tao,Qian, Hao,Zhou, Ai-Nan,Sun, Hong-Bin,Zhang, Qing-Wei,Li, Jian-Qi

supporting information, (2019/10/22)

A series of novel aralkyl piperazine and piperidine derivatives were synthesized, and evaluated for their serotonin reuptake inhibitory and 5-HT1A/5-HT7 receptors affinities activity. Antidepressant activities in vivo of the selective compound were screened using the forced swimming test (FST) and tail suspension test (TST). The results indicated that compound 19a exhibited high affinities for the 5-HT1A/5-HT7 receptors (5-HT1A, Ki = 12 nM; 5-HT7, Ki = 3.2 nM) coupled with potent serotonin reuptake inhibition (IC50 = 14 nM) and showed a marked antidepressant-like effect in the FST and TST models.

Constructing iboga alkaloids via C-H bond functionalization: Examination of the direct and catalytic union of heteroarenes and isoquinuclidine alkenes

Kruegel, Andrew C.,Rakshit, Souvik,Li, Xiaoguang,Sames, Dalibor

, p. 2062 - 2071 (2015/10/12)

The iboga alkaloids have attracted considerable attention in both the scientific community and popular media due to their reported ability to reverse or markedly diminish cravings for, and self-administration of, the major drugs of abuse. We have developed three new intramolecular C-H functionalization procedures leading to the core seven-membered ring of the iboga skeleton, a cyclization that proved to be highly challenging. The electrophilic palladium salt Pd(CH3CN)4(BF4)2 was effective for the cyclization of diverse N-(2-arylethyl)isoquinuclidines with yields of 10-35%. A two-step, bromination-reductive Heck reaction protocol was also effective for the synthesis of ibogamine in 42% yield. Finally, a direct Ni(0)-catalyzed C-H functionalization provided the benzofuran analogues of ibogamine (74%) and epi-ibogamine (38%). Although each approach suffers from significant shortcomings, in combination, the methods described provide practical routes to diverse ibogamine analogues.

SMALL MOLECULE INDUCERS OF GDNF AS POTENTIAL NEW THERAPEUTICS FOR NEUROPSYCHIATRIC DISORDERS

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Page/Page column 101; 102, (2013/03/26)

The invention provides a compound having the structure (I), wherein A is a substituted or unsubstituted ring; Z is present or absent and when present is (II), wherein n is 0, 1, 2, 3, or 4; Y is -(CR11R12)-, -NH(CR11R12)- or -O(CR11R12)- wherein R11 and R12 are each hydrogen or combine to form a carbonyl; and wherein R1 to R10 are herein as described.

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