127561-18-6

Basic information

• Product Name: 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine
• Synonyms: 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine;2-(Piperazin-1-yl)-6-(trifluoromethyl)pyridine;2-(Piperazin-1-yl)-6-(trifluoromethyl)pyridine 97%;2-(Piperazin-1-yl)-6-(trifluoromethyl)pyridine97%;2-Piperazino-6-(trifluoromethyl)pyridine;1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine 97%;2-(Piperazin-1-yl)-6-(trifluoromethyl)pyridine, 6-(Piperazin-1-yl)-alpha,alpha,alpha-trifluoro-2-picoline;1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine97%
• CAS NO: 127561-18-6
• Molecular Formula: C₁₀H₁₂F₃N₃
• Molecular Weight: 231.2175896
• EINECS: 208-076-9
• Product Categories: Pyrans, Piperidines &Piperazines;Pyridines;Pyrans, Piperidines & Piperazines;Pyridine
• Mol File: 127561-18-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 102 °C
• Flash Point: °C
• Appearance: /
• Density: 1.578g/cm³
• Vapor Pressure: 0.000378mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.45±0.10(Predicted)
• CAS DataBase Reference: 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine(127561-18-6)
• EPA Substance Registry System: 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine(127561-18-6)

Safety Data

• Hazard Codes: C,T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 127561-18-6(Hazardous Substances Data)

Usage

General Description

1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine is a chemical substance categorized under the class of organic compounds known as piperazines. The chemical, which can be identified by its Molecular Formula C10H12F3N3, is primarily used in scientific contexts, especially in research and laboratory settings. Its molecular weight is 231.217 g/mol. It falls into the subset category of alkylaryl piperazines. However, very specific and limited information is available regarding its applications or specific characteristics, possibly due to its specialized use.

InChI:InChI=1/C10H12F3N3/c11-10(12,13)8-2-1-3-9(15-8)16-6-4-14-5-7-16/h1-3,14H,4-7H2

Upstream product

• 110-85-0 piperazine 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Relevant articles and documents

Heteroaromatic acetamide derivative, preparation and applications thereof

The present invention provides a heteroaromatic acetamide derivative, a preparation and applications thereof, wherein the derivative comprises a pharmaceutically acceptable salt and/or a solvate thereof. According to the present invention, the experiment results prove that the heteroaromatic acetamide derivative can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit orreduce the activity of TRPA1, and can be used for treating diseases mediated by TRPA1; and the inhibitor of the present invention further comprises a pharmaceutical composition of the compound, and amethods for preparing the compounds. The derivative has a general formula defined in the specification.

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).

Synthesis and preliminary in vivo evaluation of 4-[18F]fluoro-N- {2-[4-(6-trifluoromethylpyridin-2-yl) piperazin-1-yl]ethyl}benzamide, a potential PET radioligand for the 5-HT1A receptor

4-Fluoro-N-{2-[4-(6-trifluoromethylpyridin-2-yl)piperazin-1-yl]ethyl} benzamide is a full 5-HT1A agonist with high affinity (pK i=9.3), selectivity and a clog P of 3.045. The corresponding PET radioligand 4-[18F]fluoro-N-{2-[4-(6-trifluoromethylpyridin-2-yl) piperazin-1-yl]ethyl}benzamide was synthesized by nucleophilic aromatic substitution on the nitro precursor. The fluorinating agent K[ 18F]F/Kryptofix 2.2.2 was both dried (9 min, 700 W) and incorporated in the precursor (5 min, 700 W) using a commercially available microwave oven. In a total synthesis time of 60 min, an overall radiochemical yield of 18% (SD=5, n=7, EOS) was obtained. Radiochemical purity was always higher than 99% and specific activity always higher than 81.4 GBq/μmol (2.2 Ci/μmol). Initial brain uptake in mice was 2.19% ID (5.47% ID/g, 2 min) but decreased rapidly (0.17% ID, 0.45% ID/g (60 min)). During the first 20 min p.i., radioactivity concentration of the brain was significantly higher than that of blood demonstrating good brain entry of the tracer. Copyright