1275611-25-0

Basic information

• Product Name: 5-[3-{2-(2,2,2-trifluoroacetylamino)-4-methylpentanoyl}-1-propynyl]-5'-O-(4,4'-dimethoxytrityl) LNA uridine
• Synonyms: 5-[3-{2-(2,2,2-trifluoroacetylamino)-4-methylpentanoyl}-1-propynyl]-5'-O-(4,4'-dimethoxytrityl) LNA uridine
• CAS NO: 1275611-25-0
• Molecular Weight: 820.819
• Mol File: 1275611-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[3-{2-(2,2,2-trifluoroacetylamino)-4-methylpentanoyl}-1-propynyl]-5'-O-(4,4'-dimethoxytrityl) LNA uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[3-{2-(2,2,2-trifluoroacetylamino)-4-methylpentanoyl}-1-propynyl]-5'-O-(4,4'-dimethoxytrityl) LNA uridine(1275611-25-0)
• EPA Substance Registry System: 5-[3-{2-(2,2,2-trifluoroacetylamino)-4-methylpentanoyl}-1-propynyl]-5'-O-(4,4'-dimethoxytrityl) LNA uridine(1275611-25-0)

Safety Data

• Hazardous Substances Data: 1275611-25-0(Hazardous Substances Data)

Upstream product

• 1480-30-4 (S)-2-(2,2,2-trifluoroacetamido)-4-methylpentanoic acid 

Relevant articles and documents

NUCLEOBASE-FUNCTIONALIZED CONFORMATIONALLY RESTRICTED NUCLEOTIDES AND OLIGONUCLEOTIDES FOR TARGETING NUCLEIC ACIDS

Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.