1275613-97-2Relevant academic research and scientific papers
Catalytic asymmetric Michael addition of α,β-unsaturated aldehydes to Ni(ii) complexes of the Schiff base of glycine
Luo, Xiaoyan,Jin, Zhichao,Li, Pengfei,Gao, Jiabin,Yue, Weimin,Liang, Xinmiao,Ye, Jinxing
, p. 793 - 801 (2011/04/16)
The conjugate addition of Ni(ii) complexes of glycine Schiff base to α,β-unsaturated aldehydes catalyzed by (S)-2- (diphenyl(trimethylsilyloxy)methyl)pyrrolidine afforded adducts in excellent yields with up to 49:1 dr and 95% ee. This method enables the construction of two adjacent chiral centers in one step, and offers an alternative route to chiral α-amino acid derivatives.
