127566-19-2Relevant articles and documents
Method for synthesizing 3-chloroimidazo[1,2-b]pyrazine
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Paragraph 0025, (2017/01/05)
The invention relates to a method for synthesizing 3-chloroimidazo[1,2-b]pyrazine. 3-aminopyridazine, a chloroacetaldehyde aqueous solution and N-chlorosuccinimide are used as raw materials. The ratio of the amount of substances of the 3-aminopyridazine to chloroacetaldehyde is 1:0.75-3.0. The ratio of the amount of substances of the 3-aminopyridazine to the N-chlorosuccinimide is 1:0.9-2.3. In appropriate solvent, reacting is conducted at the temperature of 35-145 DEG C to generate a 3-chloroimidazo[1,2-b]pyrazine crude product, and a 3-chloroimidazo[1,2-b]pyrazine pure product is obtained after purification. According to the method, the raw materials can be obtained easily, the price is reasonable, and meanwhile no heavy metal and corrosive gases are used in the preparation reaction; reacting is moderate, no special requirement for reaction equipment exists, and production can be conducted through common corrosion resistance equipment. Besides, the reaction condition is moderate.