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127566-19-2

2-chloroiMidazo[1,2-b]pyridazine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 127566-19-2 Structure

  • Basic information

    1. Product Name: 2-chloroiMidazo[1,2-b]pyridazine
    2. Synonyms: 2-chloroiMidazo[1,2-b]pyridazine
    3. CAS NO:127566-19-2
    4. Molecular Formula: C6H4ClN3
    5. Molecular Weight: 153.56906
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 127566-19-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-chloroiMidazo[1,2-b]pyridazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-chloroiMidazo[1,2-b]pyridazine(127566-19-2)
    11. EPA Substance Registry System: 2-chloroiMidazo[1,2-b]pyridazine(127566-19-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127566-19-2(Hazardous Substances Data)

127566-19-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 127566-19-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,5,6 and 6 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 127566-19:
(8*1)+(7*2)+(6*7)+(5*5)+(4*6)+(3*6)+(2*1)+(1*9)=142
142 % 10 = 2
So 127566-19-2 is a valid CAS Registry Number.

127566-19-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloroimidazo[1,2-b]pyridazine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127566-19-2 SDS

127566-19-2Upstream product

127566-19-2Downstream Products

127566-19-2Relevant articles and documents

Method for synthesizing 3-chloroimidazo[1,2-b]pyrazine

-

Paragraph 0025, (2017/01/05)

The invention relates to a method for synthesizing 3-chloroimidazo[1,2-b]pyrazine. 3-aminopyridazine, a chloroacetaldehyde aqueous solution and N-chlorosuccinimide are used as raw materials. The ratio of the amount of substances of the 3-aminopyridazine to chloroacetaldehyde is 1:0.75-3.0. The ratio of the amount of substances of the 3-aminopyridazine to the N-chlorosuccinimide is 1:0.9-2.3. In appropriate solvent, reacting is conducted at the temperature of 35-145 DEG C to generate a 3-chloroimidazo[1,2-b]pyrazine crude product, and a 3-chloroimidazo[1,2-b]pyrazine pure product is obtained after purification. According to the method, the raw materials can be obtained easily, the price is reasonable, and meanwhile no heavy metal and corrosive gases are used in the preparation reaction; reacting is moderate, no special requirement for reaction equipment exists, and production can be conducted through common corrosion resistance equipment. Besides, the reaction condition is moderate.

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

Peterson, Emily A.,Boezio, Alessandro A.,Andrews, Paul S.,Boezio, Christiane M.,Bush, Tammy L.,Cheng, Alan C.,Choquette, Deborah,Coats, James R.,Colletti, Adria E.,Copeland, Katrina W.,Dupont, Michelle,Graceffa, Russell,Grubinska, Barbara,Kim, Joseph L.,Lewis, Richard T.,Liu, Jingzhou,Mullady, Erin L.,Potashman, Michele H.,Romero, Karina,Shaffer, Paul L.,Stanton, Mary K.,Stellwagen, John C.,Teffera, Yohannes,Yi, Shuyan,Cai, Ti,La, Daniel S.

scheme or table, p. 4967 - 4974 (2012/09/07)

mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive mTOR inhibitors that demonstrate improved pharmacokinetic properties and selectivity compared to our previous leads. Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.

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