127572-62-7Relevant academic research and scientific papers
NOVEL CC-1065 ANALOGS AND THEIR CONJUGATES
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Page/Page column 160, (2010/06/17)
This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
Application of 2-Substituted Vinamidinium Salts to the Synthesis of 2,4-Disubstituted Pyrroles
Gupton, John T.,Krolikowski, Dale A.,Yu, Richard H.,Riesinger, Steve W.,Sikorski, James A.
, p. 4735 - 4740 (2007/10/02)
A variety of 2-substituted vinamidinium salts react with α-amino acid esters under basic conditions to produce 2-carbethoxy-4-substituted-pyrroles in good yield.The overall process represents a short and efficient synthesis of highly functionalized pyrrol
