127588-56-1Relevant articles and documents
New aryldithiolethione derivatives as potent histone deacetylase inhibitors
Tazzari, Valerio,Cappelletti, Graziella,Casagrande, Manolo,Perrino, Elena,Renzi, Luigi,Del Soldato, Piero,Sparatore, Anna
experimental part, p. 4187 - 4194 (2010/09/12)
A series of dithiolethione derivatives was synthesized and the in vitro HDAC inhibitory activity was tested. The most active compounds, 1 and 2, exhibited an IC50 in nM range with a strong hyperacetylation of histone H4 in A549 cells. The HDAC
OCULAR PHARMACEUTICAL COMPOSITIONS
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Page/Page column 21-23, (2009/10/22)
The present invention relates to novel derivatives of opthalmic compounds for the treatment of ocular diseases.
Cardiovascular agents
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Page/Page column 8-9, (2008/12/04)
The present invention relates to novel compounds that are derivatives of angiotensin receptor blocker (ARB) that comprise in their formula a polysulfurated group and that are useful for treating cardio-vascular diseases, such as hypertension, ischemic heart disease, atherosclerosis, metabolic syndrome, etc. also in combination with other cardiovascular agents.