127588-56-1Relevant articles and documents
New aryldithiolethione derivatives as potent histone deacetylase inhibitors
Tazzari, Valerio,Cappelletti, Graziella,Casagrande, Manolo,Perrino, Elena,Renzi, Luigi,Del Soldato, Piero,Sparatore, Anna
experimental part, p. 4187 - 4194 (2010/09/12)
A series of dithiolethione derivatives was synthesized and the in vitro HDAC inhibitory activity was tested. The most active compounds, 1 and 2, exhibited an IC50 in nM range with a strong hyperacetylation of histone H4 in A549 cells. The HDAC
NEW AGENTS FOR THE TREATMENT OF THE LOW URINARY TRACT DYSFUNCTIONS
-
, (2009/04/25)
The present invention relates to novel compounds that are derivatives of 5 -phosphodiesterase inhibitors that comprise in their formula a polysulfurated group and that are useful for treating dysfunctions of low urinary tract such as incontinence, benign prostatic hyperplasia and erectile dysfunction.
NEW ANTICANCER COMPOUNDS
-
Page/Page column 23, (2009/06/27)
The present invention relates to new polysulf urated compounds containing 2 or more sulphur atoms belonging to the class of organic thiosulf onates, or dithiole-thione derivatives cyclic or linear, or trithiocarbonates for the use alone or in combination with other anticancer treatments for the treatment and/or prevention of cancer and inflammatory diseases.
OCULAR PHARMACEUTICAL COMPOSITIONS
-
Page/Page column 21-23, (2009/10/22)
The present invention relates to novel derivatives of opthalmic compounds for the treatment of ocular diseases.
Cardiovascular agents
-
Page/Page column 8-9, (2008/12/04)
The present invention relates to novel compounds that are derivatives of angiotensin receptor blocker (ARB) that comprise in their formula a polysulfurated group and that are useful for treating cardio-vascular diseases, such as hypertension, ischemic heart disease, atherosclerosis, metabolic syndrome, etc. also in combination with other cardiovascular agents.
N2S2 tetradentate ligands for soft cationic species: preparation of new ligands of potential interest in nuclear medicine
Charbonnel-Jobic, Gaelle,Guemas, Jean-Pierre,Adelaere, Bruno,Parrain, Jean-Luc,Quintard, Jean-Paul
, p. 624 - 636 (2007/10/02)
The synthesis of N2S2 tetradentate ligands of the bis-(enaminothioester) type was carried out starting from 3-(methylthio)-3H-1,2-dithiolylium iodides and diamines.The title compounds, which are potential ligands for soft cationic species, can be obtained from 1,3-diaminopropan-2-ol and subsequently modified into the dissymmetrical succinic acid ester of the ligand and N-hydroxysuccinimide.The appendage of such a linking group on the chelating structure should allow further grafting to monoclonal antibodies in view of potential applications in nuclear medicine. 3H-1,2-dithiole-3-thione / 1,3-diaminopropan-2-ol / bis-(enaminothioester) / N2S2 tetradentate ligand / N-hydroxysuccinimidyl ester