127589-86-0

Upstream product

• 112-53-8 1-dodecyl alcohol 
• 490-79-9 2,5-dihydroxybenzoic acid. 
• 94880-44-1 2,5-bis(benzyloxy)benzoyl chloride 
• 67127-91-7 2,5-bis(benzyloxy)benzoic acid 

Relevant academic research and scientific papers

Design of antibacterial agents: Alkyl dihydroxybenzoates against xanthomonas citri subsp. citri

Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.

Bisphthalonitrile monomer containing side chain substituted aromatic ester type mesogenic unit as well as preparation and application of bisphthalonitrile monomer

The invention discloses a bisphthalonitrile monomer containing a side chain substituted aromatic ester type mesogenic unit as well as preparation and an application of the bisphthalonitrile monomer. A general formula of the bisphthalonitrile monomer containing the side chain substituted aromatic ester type mesogenic unit is represented in the specification, wherein M represents a side chain substituted aromatic group. Compared with the prior art, the bisphthalonitrile monomer has the advantages that through introduction of the mesogenic unit with a side chain, the melting temperature can be decreased, and the resin can be widely applied to a liquid crystal polymer material; according to the related monomer preparation method, the synthesis period is greatly shortened, raw materials for monomer synthesis are cheap and easily available, the preparation method is simple and convenient, and the yield is high.