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CAS

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127590-67-4

[1-((2R,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-5-(thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 127590-67-4 Structure

  • Basic information

    1. Product Name: [1-((2R,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-5-(thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
    2. Synonyms: [1-((2R,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-5-(thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
    3. CAS NO:127590-67-4
    4. Molecular Formula:
    5. Molecular Weight: 427.44
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 127590-67-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [1-((2R,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-5-(thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: [1-((2R,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-5-(thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester(127590-67-4)
    11. EPA Substance Registry System: [1-((2R,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-5-(thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester(127590-67-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127590-67-4(Hazardous Substances Data)

127590-67-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 127590-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,5,9 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127590-67:
(8*1)+(7*2)+(6*7)+(5*5)+(4*9)+(3*0)+(2*6)+(1*7)=144
144 % 10 = 4
So 127590-67-4 is a valid CAS Registry Number.

127590-67-4Downstream Products

127590-67-4Relevant articles and documents

Synthesis and antineoplastic activity of alanyl-2-glycyl peptide derivatives of nocodazole

Ross, Stephen T.,Kruse, Lawrence I.,Kingsbury, William D.,Erhard, Karl F.,Harrsch, Peter B.,et al.

, p. 363 - 370 (1989)

To provide the antineoplastic agent nocodazole, 1, with improved solubility and drug-transport properties, the (S)-alanyl-2-glycyl moiety was introduced as a benzimidazole-nitrogen-substituent which would be expected to be enzymatically cleaved in vivo to regenerate 1 and achieve enhanced antineoplastic effectiveness.Synthesis produced 2 pairs of diastereo-isomers (2a-d) which were separated and purified by solubility and chromatography.Site of substitution (N1 vs.N3) and chirality were established by 1H NMR nOe difference spectra and CD spectra on 2a-d and derivatives.The compounds were evaluated in cytotoxity, leukemia, and solid tumor models and as inhibitors of tubulin binding.These test results indicated that these compounds were not functioning as produgs for 1.However, the solid tumor model study showed that 2 compounds had equivalent to enhanced antitumor effectiveness over 1 itself.Keywords - antineoplastic activity / ADJ-PC6 plasmacytoma activity / prodrug /nocodazole / alanyl-2-glycyl peptides / tubulin

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