1275930-89-6

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 20781-20-8 2,4-Dimethoxybenzylamine 

Downstream Products

• 1354787-42-0 tert-butyl 4-(4-(4-(2-chloro-4-(N-(2,4-dimethoxybenzyl)-N-(pyrimidin-4-yl)sulfamoyl)-5-fluorophenoxy)-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate 
• 1354787-43-1 5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2,4-difluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide 
• 1354787-44-2 N-[(2,4-dimethoxyphenyl)methyl]pyrimidin-4-amine 
• 1450598-94-3 5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide 

Relevant academic research and scientific papers

METHOD FOR REMOVING DIMETHOXYBENZYL GROUP

In a method for producing a de-dimethoxybenzylated compound by removing a dimethoxybenzyl group from a compound containing a dimethoxybenzyl group bonded to a nitrogen atom in the presence of an acid, the de-dimethoxybenzylated compound is obtained by rem

Chemical Compounds

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z1, Ra, Rb, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.